https://www.acmrjournal.com/index.php/ACMR/issue/feed 2024-04-28T17:19:00+00:00 Editor, ACMR editor@acmrjournal.com Open Journal Systems <p style="text-align: justify;"><img src="https://www.acmrjournal.com/archive/wp-content/uploads/2023/04/cover_issue_9_en_US-scaled-e1682543908435.jpg" alt="" width="311" height="440" /></p> <p style="text-align: justify;">The Advances in Clinical Medical Research (ACMR) Journal was started in 2018 with the aim to provide the recent trends in biomedical arena. The Advances in Clinical Medical Research is an online and print peer-reviewed journal which welcomes papers dealing with all aspects of medical and surgical specialties. Advances in Clinical Medical Research publishes high quality research and reviews and aims to ensure that the results of all well-conducted research are published, regardless of their outcome.</p> <p style="text-align: justify;">ACMR publishes a wide variety of research in preclinical and clinical area of global interest across all medical disciplines, enabling clinicians and other researchers to learn about developments and innovations within these disciplines and across the boundaries between disciplines. The journal publishes 4 issues per year (Quarterly). Original research articles, brief communications, review articles, case report/series or letter to editor may be submitted.</p> https://www.acmrjournal.com/index.php/ACMR/article/view/66 2024-04-28T17:10:28+00:00 Munisa Abdushukurovna Mirsaidova munisa876@mail.com Malika Turakhanovna Alisheva rohitmaxy@gmail.com

<p><strong>Purpose:</strong> This study aims to investigate the role of disturbances in vaginal microbiocenosis in recurrent urogenital candidiasis (UGC), focusing on the type of fungus present and the bacterial mass, using PCR diagnostics. <strong>Methods:</strong> Twenty-two women diagnosed with chronic vulvovaginal candidiasis were examined. PCR diagnostics, including the Mycoso-Screen analysis for fungal pathogens and the Femoflor-16 PCR test system for vaginal dysbiosis, were performed to determine the type of fungus and bacterial mass present. <strong>Results:</strong> Candida albicans was found in 36% of patients, Candida glabrata in 32%, Debaryomyces hansenii in 12%, Pichia kudriavzevii in 12%, and Saccharomyces cerevisiae in 12%. Moreover, dysbiosis of vaginal microbiota was observed in 77% of patients, characterized by decreased lactobacilli and increased opportunistic microflora, contributing to the recurrence of UGC. <strong>Conclusion: </strong>Recurrent urogenital candidiasis is influenced by various factors, including the properties of yeast fungi and disturbances in vaginal microbiota. Comprehensive treatment addressing both fungal and bacterial components of dysbiosis may provide better therapeutic outcomes and reduce the recurrence of UGC. Further research is warranted to elucidate the mechanisms underlying these interactions and optimize treatment strategies.</p>

2024-04-28T00:00:00+00:00 Copyright (c) 2024 Advances in Clinical Medical Research https://www.acmrjournal.com/index.php/ACMR/article/view/67 2024-04-28T17:13:27+00:00 Sada GH. Taher sada2020.bio@utq.edu.iq

<p>The aim of the study is to see how Dexamethasone affects the liver of pregnant Swiss albino mice at various stages of development. The study included Fifty-four pregnant female mice that divided into three cohorts at random. There are 18 pregnant mice in each group. Each member was injected with different doses of Dexamethasone into a specific tail vein at different times. The control group, on the other hand, received standard saline injections. The mice were then killed at days 13, 15 and 17.&nbsp; And the results illustrated that when different dosages of Dexamethasone were used at different periods, the results demonstrated a negative effect on the liver of pregnant mice. These effects were stronger as the number and concentration of medication doses increased. Dexamethasone produces morphological abnormalities in the liver such as necrosis, vascular congestion, binucleated cells, and microabscesses involving hepatocytes and inflammatory cells. In conclusion, the use of Dexamethasone shows different changes in the liver tissue, including necrosis, Binucleated cells, vascular congestion and micro abscess when it was used for a long-term exposure or by repeating doses.</p>

2024-04-28T00:00:00+00:00 Copyright (c) 2024 Advances in Clinical Medical Research