Effects of Yoga on Blood Pressure and Malondialdehyde (MDA) in Mild Hypertensive Patients
DOI:
https://doi.org/10.48112/acmr.v1i1.9Keywords:
Yoga, hypertension, MDA, CVDAbstract
Abstract Views: 65
Cardiovascular diseases (CVD) is considered a prominent cause of mortality. Essential hypertension is regarded as the most important risk factor for CVD in modern society despite advanced and effective management. Malondialdehyde (MDA), an indicator of oxidative stress, is produced by the oxidation of polyunsaturated fatty acid. Nadishodhan pranayam leads to decrease stress as well as blood pressure. It was an interventional type of study done between January 2020 to May 2020. Ninety-seven mild hypertensive patients (53 males and 44 females) of group I completed the yoga program. While fifty normotensive subjects were included as a control in group II. Blood pressure and MDA were measured of every participant before and after three months of the yoga program. Total ninety-seven mild hypertensive patients of age 33.6± 8.66 years of group I completed three months yoga program. However, fifty subjects (34.7 ± 7.73 years)of group II had not done any yogic exercise for three months. This study showed a significant difference in SBP (p<0.001), DBP (p<0.001), HR (p<0.001), PP (p<0.001) and MAP (p<0.001) group I mild hypertensive patients after following three months yoga program. There was a significant difference between before and after the yoga program MDA level of group I mild hypertensive patients. However, there was an insignificant difference between before and after three months level of MDA in group II control subjects. In this study, it has been observed that the daily practice of yoga improves the blood pressure of mildly hypertensive patients. Moreover, it substantially decreases oxidative stress. Yoga can be an effective alternative to reduce blood pressure in mild hypertensive patients either with medication or without medication.
References
Mozaffarian D, Wilson PWF, Kannel WB. Beyond Established and Novel Risk Factors. Circulation. 2008;117(23):3031–3038. Available from: https://dx.doi.org/10.1161/circulationaha.107.738732
Carretero OA, Oparil S. Essential hypertension: Part I: definition and etiology. Circulation. 2000;101:329–364. Available from: https://doi.org/10.1161/01.cir.101.3.329
Kuklinska AM, Mroczho B, Musical WJ, Usowicz-Szarynska M, Sawicki R, Borowska H. Diagnostic biomarkers of essential arterial hypertension: the value of prostacyclin, nitric oxide, oxidized - LDL, and peroxide measurements. Int Heart J. 2009;5:341–51. Available from: https://doi.org/10.1536/ihj.50.341
Sodium, potassium, body mass, alcohol and blood pressure: the intersalt study. J Hypertens. 1988;6:584–590.
Sever PS, Poulter NR. A hypothesis for the pathogenesis of essential hypertension: the initiating factors. J Hypertens. 1989;7(Supplement 1):9–12. Available from: https://dx.doi.org/10.1097/00004872-198902001-00004
Whelton PK. Epidemiology of hypertension. Lancet. 1994;344(8915):101–106. Available from: https://dx.doi.org/10.1016/s0140-6736(94)91285-8
Kunwar A, Priyadarsini KI. Free radicals, oxidative stress and importance of antioxidants in human health. J Med Allied Sci. 2011;1(2):53–60.
Yadav RK, Ray RB, Vempati R, Bijlani RL. Effect of a comprehensive yoga-based lifestyle modification program on lipid peroxidation. Indian J Physiol Pharmacol. 2005;49(3):358–62.
Montezano AC, Touyz RM. Reactive Oxygen Species, Vascular Noxs, and Hypertension: Focus on Translational and Clinical Research. Antioxid Redox Signal. 2014;20(1):164–182. Available from: https://dx.doi.org/10.1089/ars.2013.5302
Walter MF, Jacob RF, Jeffers B, Ghadanfar MM, Preston GM, Buch J, et al. Serum levels of thiobarbituric acid reactive substances predict cardiovascular events in patients with stable coronary artery disease. J Am Coll Cardiol. 2004;44(10):1996–2002. Available from: https://dx.doi.org/10.1016/j.jacc.2004.08.029
Okonta NR. Does Yoga Therapy Reduce Blood Pressure in Patients With Hypertension? Holist Nurs Pract. 2012;26(3):137–141. Available from: https://dx.doi.org/10.1097/hnp.0b013e31824ef647
Agte VV, Jahagirdar, Tarwadi KV. The effects of SudarshanKriya Yoga on some physiological and biochemical parameters in mild hypertensive patients. Indian J Physiol Pharmacol. 2011;55(2):183–190.
Shete S, Bera T, Mahapure H. Effect of yogic exercise on super oxide dismutase levels in diabetics. Int J Yoga. 2008;1(1):21–26. Available from: https://dx.doi.org/10.4103/0973-6131.36792
Sinha S, Singh SN, Monga YP, Ray US. Improvement of Glutathione and Total Antioxidant Status with Yoga. J Altern Complement Med. 2007;13(10):1085–1090. Available from: https://dx.doi.org/10.1089/acm.2007.0567
Bhattacharya S, Pandey US, Verma NS. Improvement in oxidative status with yogic breathing in young healthy males. Indian J Physiol Pharmacol. 2002;46(3):349–354.
Subbalakshmi NK, Saxena SK, Urmimala D, Souza U. Immediate effect of 'Nadi-Shodhana Pranayama' on some selected parameters of cardiovascular, pulmonary, and higher functions of the brain. Thai J Physiol Sci. 2005;18(2):10–16.
Sukhdev S, Vishaw G, Ved P. Effects of a 6-week nadi-shodhana pranayama training on cardio-pulmonary parameters. J Physical Educ Sports Manage. 2011;2(4):44–51.
Frisoli TM, Schmieder RE, Grodzicki T, Messerli FH. Beyond salt: lifestyle modifications and blood pressure. Eur Heart J. 2011;32(24):3081–3087. Available from: https://dx.doi.org/10.1093/eurheartj/ehr379
Mossa MM, Bushra MM, Salih MR, May NY. Estimation of malondialdehyde as oxidative factor & glutathione as early detectors of hypertensive pregnant women. Tikrit Med J. 2009;15(2):63–72.
Svetkey LP, Erlinger TP, Vollmer WM, Feldstein A, Cooper LS, Appel LJ, et al. Effect of lifestyle modifications on blood pressure by race, sex, hypertension status, and age. Journal of Human Hypertension 2005;19(1):21–31. Available from: https://dx.doi.org/10.1038/sj.jhh.1001770
Moriguchi J, Itoh H, Harada S, Takeda K, Hatta T, Nakata T, et al. Low Frequency Regular Exercise Improves Flow-Mediated Dilatation of Subjects with Mild Hypertension. Hypertens Res. 2005;28(4):315–321. Available from: https://dx.doi.org/10.1291/hypres.28.315
Pal GK, Chandrasekaran A, Hariharan AP, Dutta TK, Pal P, Nanda N, et al. Body mass index contributes to sympathovagal imbalance in prehypertensives. BMC Cardiovasc Disord. 2012;12(1):54. Available from: https://dx.doi.org/10.1186/1471-2261-12-54
Santella DF, Araujo EA, Ortega KC, Tinucci T, Mion D, Negrao CE. After effects of exercise and relaxation on blood pressure. Clin J Sport Med. 2006;16(4):341–348. Available from: https://doi.org/10.1097/00042752-200607000-00010
Tyagi A, Cohen M. Yoga and hypertension: a systematic review. Altern Ther Health Med. 2014;20(2):32–59.
Alfadda AA, Sallam RM. Reactive Oxygen Species in Health and Disease. J Biomed Biotechnol. 2012;2012:1–14. Available from: https://dx.doi.org/10.1155/2012/936486
Aggarwal NT, Makielski JC. Redox Control of Cardiac Excitability. Antioxid Redox Sign. 2013;18(4):432–468. Available from: https://dx.doi.org/10.1089/ars.2011.4234
Sohal RS, Mockett RJ, Orr WC. Mechanisms of aging: an appraisal of the oxidative stress hypothesis1,2 1This article is part of a series of reviews on “Oxidative Stress and Aging.” The full list of papers may be found on the homepage of the journal. 2Guest Editor: Rajindar S. Sohal. Free Radic Biol Med. 2002;33(5):575–586. Available from: https://dx.doi.org/10.1016/s0891-5849(02)00886-9
Bobby Z, Pavithran P, Agrawal A, Selvaraj N, Nandeesha H, Sathiyapriya V. Altered oxidant-antioxidant status in non-obese men with moderate essential hypertension. Indian J Med Sci. 2007;61(6):326. Available from: https://dx.doi.org/10.4103/0019-5359.32679
Subash P, Premagurumurthy K, Sarasabharathi A, Cherian KM. Total antioxidant status and oxidative DNA damage in a South Indian population of essential hypertensives. J Hum Hypertens. 2010;24(7):475–482. Available from: https://dx.doi.org/10.1038/jhh.2009.100
Gordon LA, Morrison EY, McGrowder DA, Young R, Fraser YTP, Zamora EM, et al. Effect of exercise therapy on lipid profile and oxidative stress indicators in patients with type 2 diabetes. BMC Compl Alternative Med. 2008;8(1):21. Available from: https://dx.doi.org/10.1186/1472-6882-8-21
Patil SG, Dhanakshirur GB, Aithala MR, Naegal G, Das KK. Effect of yoga on oxidative stress in elderly with grade-I hyper¬tension: a randomized controlled study. J Clin Diabn Res. 2014;8(7):4–7. Available from: https://doi.org/10.7860/jcdr/2014/9498.4586
Singh S, Malhotra V, Singh KP, Sharma SB, Madhu SV, Tandon OP. A preliminary report on the role of yoga asanas on oxidative stress in non-insulin dependent diabetes mellitus. Indian J Clin Biochem. 2001;16(2):216–220. Available from: https://dx.doi.org/10.1007/bf02864866
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