Peculiarities of Cytokine Status and Biochemical Indicators in Bronchial Asthma in Children
DOI:
https://doi.org/10.48112/acmr.v2i3.19Keywords:
Bronchial Asthma, Cytokine Status, Hemostasis, Acid-Base State, ChildrenAbstract
Abstract Views: 30
The article studies the indicators of the cytokine status and determines the features of the hemostasis system and acid-base state in bronchial asthma in children. We examined 25 children with bronchial asthma in the period of exacerbation at the age from 7 to 14 years, who received treatment in the department of allergology, the comparison group consisted of 20 patients with bronchial asthma in the remission phase, the control group consisted of 10 practically healthy children of the same age. From the side of biochemical parameters, a very low level of prothrombin time, mild metabolic alkalosis, low partial pressure of oxygen in the blood, and a decrease in the concentration of potassium and calcium ions were revealed. This is caused by disturbances in the hemostasis system, due to long-term persistent inflammation in the bronchopulmonary system and severe hypoxia.
References
Trivedi, Michelle & Denton, Eve . 2019. Asthma in Children and Adults—What Are the Differences and What Can They Tell us About Asthma? Front Pediatr. 7:256.
Aalderen, Wim M. van . 2012. Childhood Asthma: Diagnosis and Treatment. Scientifica (Cairo). 2012:674204.
Boyd, Scott Dexter, Hoh, Ramona Amy, Nadeau, Kari Christine & Galli, Stephen Joseph . 2017. Immune monitoring for precision medicine in allergy and asthma. Curr Opin Immunol. 48:82–91.
Chad, Zave . 2001. Allergies in children. Paediatr Child Health. 6(8):555–566.
Subbarao, Padmaja, Mandhane, Piush J. & Sears, Malcolm R. . 2009. Asthma: epidemiology, etiology and risk factors. CMAJ 18(19):181–190.
Smith, Stephanie A., Travers, Richard J. & Morrissey, James H. . 2015. How it all starts: initiation of the clotting cascade. Crit Rev Biochem Mol Biol. 50(4):326–336.
Palta, Sanjeev, Saroa, Richa & Palta, Anshu . 2014. Overview of the coagulation system. Indian J Anaesth. 58(5):515–523.
Kudo, Makoto, Ishigatsubo, Yoshiaki & Aoki, Ichiro . 2013. Pathology of asthma. Frontiers in Microbiology 4:263.
I Tillie-Leblond, Pugin, J, Marquette, C H, Lamblin, C, Saulnier, F & Brichet, A . 1999. Balance between Proinflammatory Cytokines and Their Inhibitors in Bronchial Lavage from Patients with Status Asthmaticus. Am J Respir Crit Care Med. 159(2):487–494.
Xin, Lei, Gao, Junjie, Ge, Xiahui, Tian, Chenxuan, Ma, Weirong & Tian, Zhigang . 2018. Increased pro-inflammatory cytokine-secreting regulatory T cells are correlated with the plasticity of T helper cell differentiation and reflect disease status in asthma. Respir Med. 143:129–138.
Gaballah, Hanaa H., Gaber, Rasha A., Sharshar, Ragia S. & Elshweikh, Samah A. . 2018. NOD2 expression, DNA damage and oxido-inflammatory status in atopic bronchial asthma: Exploring their nexus to disease severity. Gene 660:128–135.
Ivanchuk, Yuliya, Tribuntceva, Ludmila, Budnevsky, Andrey, Shkatova, Yanina, Ovsyannikov, Evgeniy & Tokmachev, Roman . 2021. Life Quality and Cytokines Profile in Patients with Asthma and Osteoarthritis. Int J Biomed. 11(2):137–140.
Johansson, Mats W. . 2017. Eosinophil Activation Status in Separate Compartments and Association with Asthma. Front Med. 4:75.
Knight-Madden, Jennifer, Vergani, Diego, Patey, Richard, Sylvester, Karl, Hussain, Munther J. & Forrester, Terrence . 2012. Cytokine Levels and Profiles in Children Related to Sickle Cell Disease and Asthma Status. J Interferon Cytokine Res. 32(1):1–5.
Subrahmanyam, RoopakalaMysore, Srikantaiah, Chandrashekara, Krishna, Pushpa, Silvia, Chickbllapur RayappaWilma Delphine, Thirunavukkarasu, Sandeep & Devi, Kusuma . 2011. Can bronchial asthma be classified based on the immunological status? Lung India 28(2):110.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Advances in Clinical Medical Research
This work is licensed under a Creative Commons Attribution 4.0 International License.
OAI-PMH 
